4i12: Difference between revisions
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{{STRUCTURE_4i12| PDB=4i12 | SCENE= }} | {{STRUCTURE_4i12| PDB=4i12 | SCENE= }} | ||
===Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors=== | ===Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors=== | ||
{{ABSTRACT_PUBMED_23570791}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4i12]] is a 1 chain structure | [[4i12]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA]. | ||
[[ | |||
==See Also== | |||
*[[Beta secretase|Beta secretase]] | |||
==Reference== | |||
<ref group="xtra">PMID:023570791</ref><references group="xtra"/><references/> | |||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Brecht, E]] | [[Category: Brecht, E]] | ||
