3ht2: Difference between revisions

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[[Image:3ht2.png|left|200px]]
==Zink containing polyketide cyclase RemF from Streptomyces resistomycificus==
<StructureSection load='3ht2' size='340' side='right' caption='[[3ht2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ht2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_resistomycificus Streptomyces resistomycificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HT2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ht1|3ht1]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">remF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67356 Streptomyces resistomycificus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ht2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ht2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ht2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ht2 PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/3ht2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RemF is a polyketide cyclase involved in the biosynthesis of the aromatic pentacyclic metabolite resistomycin in Streptomyces resistomycificus. The enzyme is a member of a structurally hitherto uncharacterized class of polyketide cyclases. The crystal structure of RemF was determined by SAD and refined to 1.2 A resolution. The enzyme subunit shows a beta-sandwich structure with a topology characteristic for the cupin fold. RemF contains a metal binding site located at the bottom of the predominantly hydrophobic active site cavity. A zinc ion is coordinated to four histidine side chains, and two water molecules in octahedral ligand sphere geometry, highly unusual for zinc binding sites in proteins.


{{STRUCTURE_3ht2|  PDB=3ht2  |  SCENE=  }}
The polyketide cyclase RemF from Streptomyces resistomycificus contains an unusual octahedral zinc binding site.,Silvennoinen L, Sandalova T, Schneider G FEBS Lett. 2009 Sep 3;583(17):2917-21. Epub 2009 Aug 6. PMID:19665022<ref>PMID:19665022</ref>


===Zink containing polyketide cyclase RemF from Streptomyces resistomycificus===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_19665022}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3ht2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_resistomycificus Streptomyces resistomycificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HT2 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:019665022</ref><references group="xtra"/>
[[Category: Streptomyces resistomycificus]]
[[Category: Streptomyces resistomycificus]]
[[Category: Sandalova, T.]]
[[Category: Sandalova, T]]
[[Category: Schneider, G.]]
[[Category: Schneider, G]]
[[Category: Silvennoinen, L.]]
[[Category: Silvennoinen, L]]
[[Category: Antibiotic biosynthesis]]
[[Category: Antibiotic biosynthesis]]
[[Category: Cupin fold]]
[[Category: Cupin fold]]
Retrieved from "https://proteopedia.org/3ht2"