2azr: Difference between revisions

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[[Image:2azr.gif|left|200px]]<br /><applet load="2azr" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2azr.gif|left|200px]]
caption="2azr, resolution 2.0&Aring;" />
 
'''Crystal structure of PTP1B with Bicyclic Thiophene inhibitor'''<br />
{{Structure
|PDB= 2azr |SIZE=350|CAPTION= <scene name='initialview01'>2azr</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=982:3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID'>982</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of PTP1B with Bicyclic Thiophene inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AZR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=982:'>982</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZR OCA].  
2AZR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZR OCA].  


==Reference==
==Reference==
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16303309 16303309]
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16303309 16303309]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Zhang, Y L.]]
[[Category: Zhang, Y L.]]
[[Category: 982]]
[[Category: 982]]
[[Category: bicyclic thiophenes]]
[[Category: bicyclic thiophene]]
[[Category: hydrolyase]]
[[Category: hydrolyase]]
[[Category: protein tyrosine phosphatase]]
[[Category: protein tyrosine phosphatase]]


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