3hag: Difference between revisions
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[[ | ==Crystal structure of the Hepatitis E Virus-like Particle== | ||
<StructureSection load='3hag' size='340' side='right' caption='[[3hag]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3hag]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_type_4 Hepatitis e virus type 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HAG FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hag OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hag RCSB], [http://www.ebi.ac.uk/pdbsum/3hag PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Hepatitis E virus (HEV), a small, non-enveloped RNA virus in the family Hepeviridae, is associated with endemic and epidemic acute viral hepatitis in developing countries. Our 3.5-A structure of a HEV-like particle (VLP) shows that each capsid protein contains 3 linear domains that form distinct structural elements: S, the continuous capsid; P1, 3-fold protrusions; and P2, 2-fold spikes. The S domain adopts a jelly-roll fold commonly observed in small RNA viruses. The P1 and P2 domains both adopt beta-barrel folds. Each domain possesses a potential polysaccharide-binding site that may function in cell-receptor binding. Sugar binding to P1 at the capsid protein interface may lead to capsid disassembly and cell entry. Structural modeling indicates that native T = 3 capsid contains flat dimers, with less curvature than those of T = 1 VLP. Our findings significantly advance the understanding of HEV molecular biology and have application to the development of vaccines and antiviral medications. | |||
Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding.,Guu TS, Liu Z, Ye Q, Mata DA, Li K, Yin C, Zhang J, Tao YJ Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12992-7. Epub 2009 Jul 21. PMID:19622744<ref>PMID:19622744</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Hepatitis e virus type 4]] | [[Category: Hepatitis e virus type 4]] | ||
[[Category: Guu, T S.Y | [[Category: Guu, T S.Y]] | ||
[[Category: Li, K | [[Category: Li, K]] | ||
[[Category: Liu, Z | [[Category: Liu, Z]] | ||
[[Category: Mata, D A | [[Category: Mata, D A]] | ||
[[Category: Tao, Y J | [[Category: Tao, Y J]] | ||
[[Category: Ye, Q | [[Category: Ye, Q]] | ||
[[Category: Yin, C | [[Category: Yin, C]] | ||
[[Category: Zhang, J | [[Category: Zhang, J]] | ||
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
[[Category: Jelly-roll beta sheet]] | [[Category: Jelly-roll beta sheet]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
Revision as of 09:31, 8 December 2014
Crystal structure of the Hepatitis E Virus-like Particle
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