3hb0: Difference between revisions
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{{STRUCTURE_3hb0| PDB=3hb0 | SCENE= }} | {{STRUCTURE_3hb0| PDB=3hb0 | SCENE= }} | ||
===Structure of edeya2 complexed with bef3=== | ===Structure of edeya2 complexed with bef3=== | ||
{{ABSTRACT_PUBMED_19858093}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/EYA2_HUMAN EYA2_HUMAN]] Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.<ref>PMID:19351884</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3hb0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3hb0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HB0 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019858093</ref><references group="xtra"/> | <ref group="xtra">PMID:019858093</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Jeong, D G.]] | [[Category: Jeong, D G.]] | ||
