Aerolysin

File:1pre.png

Crystal Structure of Proaerolysin 1pre

Aerolysin (Aer) is a channel-forming toxin from Aeromonas hydrophyla. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, i.e. the crystal structure of Proaerolysin (1pre). For toxins in Proteopedia see Toxins.

3D Structures of Aerolysin

Updated on 13-November-2014

{"openlevels":0}

• Aerolysin

• • 3g4n, 3g4o – Aer (mutant)
• Proaerolysin
  • 1pre - proAer
    
  • 3c0m, 3c0n, 1z52 - proAer (mutant)
    
  • 3c0o - proAer (mutant)+mannose-6-phosphate

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel