3k71: Difference between revisions

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===Structure of integrin alphaX beta2 ectodomain===

==Disease==

[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref><ref>PMID:1346613</ref><ref>PMID:1968911</ref><ref>PMID:1694220</ref><ref>PMID:1590804</ref><ref>PMID:1352501</ref><ref>PMID:1347532</ref><ref>PMID:7686755</ref><ref>PMID:9884339</ref><ref>PMID:20529581</ref><ref>PMID:20549317</ref>

==Function==

[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Chen, X.]]

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@@ Line 3: / Line 3: @@
 ===Structure of integrin alphaX beta2 ectodomain===
 {{ABSTRACT_PUBMED_20033057}}
+==Disease==
+[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref><ref>PMID:1346613</ref><ref>PMID:1968911</ref><ref>PMID:1694220</ref><ref>PMID:1590804</ref><ref>PMID:1352501</ref><ref>PMID:1347532</ref><ref>PMID:7686755</ref><ref>PMID:9884339</ref><ref>PMID:20529581</ref><ref>PMID:20549317</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
 ==About this Structure==
@@ Line 11: / Line 17: @@
 ==Reference==
-<ref group="xtra">PMID:020033057</ref><references group="xtra"/>
+<ref group="xtra">PMID:020033057</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Chen, X.]]