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{{Large structure}}
==Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit==
{{STRUCTURE_3i55| PDB=3i55  | SCENE= }}
<StructureSection load='3i55' size='340' side='right' caption='[[3i55]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
===Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit===
== Structural highlights ==
{{ABSTRACT_PUBMED_19738021}}
<table><tr><td colspan='2'>[[3i55]] is a 31 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui] and [http://en.wikipedia.org/wiki/Haloarcula_marismortui_atcc_43049 Haloarcula marismortui atcc 43049]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I55 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYL:MYCALAMIDE+A'>MYL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=5AA:N6-DIMETHYL-3-AMINO-ADENOSINE-5-MONOPHOSPHATE'>5AA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PO2:HYPOPHOSPHITE'>PO2</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i56|3i56]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i55 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i55 RCSB], [http://www.ebi.ac.uk/pdbsum/3i55 PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i55_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.


==About this Structure==
Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.,Gurel G, Blaha G, Steitz TA, Moore PB Antimicrob Agents Chemother. 2009 Dec;53(12):5010-4. Epub 2009 Sep 8. PMID:19738021<ref>PMID:19738021</ref>
[[3i55]] is a 31 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui] and [http://en.wikipedia.org/wiki/Haloarcula_marismortui_atcc_43049 Haloarcula marismortui atcc 43049]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I55 OCA].
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


==See Also==
==See Also==
*[[Ribosomal protein L10|Ribosomal protein L10]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosomal protein L11|Ribosomal protein L11]]
== References ==
*[[Ribosomal protein L13|Ribosomal protein L13]]
<references/>
*[[Ribosomal protein L14|Ribosomal protein L14]]
__TOC__
*[[Ribosomal protein L19|Ribosomal protein L19]]
</StructureSection>
*[[Ribosomal protein L2|Ribosomal protein L2]]
*[[Ribosomal protein L21|Ribosomal protein L21]]
*[[Ribosomal protein L3|Ribosomal protein L3]]
*[[Ribosomal protein L34|Ribosomal protein L34]]
*[[Ribosomal protein L4|Ribosomal protein L4]]
*[[Ribosomal protein L5|Ribosomal protein L5]]
*[[Ribosomal protein L6|Ribosomal protein L6]]
*[[Ribosomal protein L7|Ribosomal protein L7]]
 
==Reference==
<ref group="xtra">PMID:019738021</ref><references group="xtra"/>
[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui atcc 43049]]
[[Category: Haloarcula marismortui atcc 43049]]
[[Category: Blaha, G.]]
[[Category: Blaha, G]]
[[Category: Gurel, G.]]
[[Category: Gurel, G]]
[[Category: Moore, P B.]]
[[Category: Moore, P B]]
[[Category: Steitz, T A.]]
[[Category: Steitz, T A]]
[[Category: Large ribosomal subunit]]
[[Category: Large ribosomal subunit]]
[[Category: Metal-binding]]
[[Category: Metal-binding]]
Retrieved from "https://proteopedia.org/3i55"