2ban: Difference between revisions

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[[Image:2ban.gif|left|200px]]<br /><applet load="2ban" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ban.gif|left|200px]]
caption="2ban, resolution 2.950&Aring;" />
 
'''Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208'''<br />
{{Structure
|PDB= 2ban |SIZE=350|CAPTION= <scene name='initialview01'>2ban</scene>, resolution 2.950&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=357:5-ETHYL-3-[(2-METHOXYETHYL)METHYLAMINO]-6-METHYL-4-(3-METHYLBENZYL)PYRIDIN-2(1H)-ONE'>357</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE=
}}
 
'''Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BAN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=357:'>357</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAN OCA].  
2BAN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAN OCA].  


==Reference==
==Reference==
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains., Himmel DM, Das K, Clark AD Jr, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E, J Med Chem. 2005 Dec 1;48(24):7582-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16302798 16302798]
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains., Himmel DM, Das K, Clark AD Jr, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E, J Med Chem. 2005 Dec 1;48(24):7582-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16302798 16302798]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: 357]]
[[Category: 357]]
[[Category: MN]]
[[Category: MN]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: hiv]]
[[Category: hiv]]
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[[Category: rt]]
[[Category: rt]]


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