2bdf: Difference between revisions

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[[Image:2bdf.jpg|left|200px]]<br /><applet load="2bdf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bdf.jpg|left|200px]]
caption="2bdf, resolution 2.1&Aring;" />
 
'''Src kinase in complex with inhibitor AP23451'''<br />
{{Structure
|PDB= 2bdf |SIZE=350|CAPTION= <scene name='initialview01'>2bdf</scene>, resolution 2.1&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=24A:{[(4-{[2-(4-AMINOCYCLOHEXYL)-9-ETHYL-9H-PURIN-6-YL]AMINO}PHENYL)(HYDROXY)PHOSPHORYL]METHYL}PHOSPHONIC ACID'>24A</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
|GENE= SRC, SRC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Src kinase in complex with inhibitor AP23451'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BDF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=24A:'>24A</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDF OCA].  
2BDF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDF OCA].  


==Reference==
==Reference==
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds., Dalgarno D, Stehle T, Narula S, Schelling P, van Schravendijk MR, Adams S, Andrade L, Keats J, Ram M, Jin L, Grossman T, MacNeil I, Metcalf C 3rd, Shakespeare W, Wang Y, Keenan T, Sundaramoorthi R, Bohacek R, Weigele M, Sawyer T, Chem Biol Drug Des. 2006 Jan;67(1):46-57. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16492148 16492148]
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds., Dalgarno D, Stehle T, Narula S, Schelling P, van Schravendijk MR, Adams S, Andrade L, Keats J, Ram M, Jin L, Grossman T, MacNeil I, Metcalf C 3rd, Shakespeare W, Wang Y, Keenan T, Sundaramoorthi R, Bohacek R, Weigele M, Sawyer T, Chem Biol Drug Des. 2006 Jan;67(1):46-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16492148 16492148]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: src kinase inhibitor]]
[[Category: src kinase inhibitor]]


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