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==STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION== | |||
<StructureSection load='1htm' size='340' side='right' caption='[[1htm]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered. | |||
Structure of influenza haemagglutinin at the pH of membrane fusion.,Bullough PA, Hughson FM, Skehel JJ, Wiley DC Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525<ref>PMID:8072525</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Hemagglutinin|Hemagglutinin]] | *[[Hemagglutinin|Hemagglutinin]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Hemagglutinin]] | [[Category: Hemagglutinin]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Uncultured beta proteobacterium umtra-608]] | [[Category: Uncultured beta proteobacterium umtra-608]] | ||
[[Category: Bullough, P A | [[Category: Bullough, P A]] | ||
[[Category: Hughson, F M | [[Category: Hughson, F M]] | ||
[[Category: Skehel, J J | [[Category: Skehel, J J]] | ||
[[Category: Wiley, D C | [[Category: Wiley, D C]] | ||
[[Category: Influenza virus hemagglutinin]] | [[Category: Influenza virus hemagglutinin]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
