2bgd: Difference between revisions

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[[Image:2bgd.gif|left|200px]]<br /><applet load="2bgd" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bgd.gif|left|200px]]
caption="2bgd, resolution 2.40&Aring;" />
 
'''STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS'''<br />
{{Structure
|PDB= 2bgd |SIZE=350|CAPTION= <scene name='initialview01'>2bgd</scene>, resolution 2.40&Aring;
|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=T1D:5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE'>T1D</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
|GENE=
}}
 
'''STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BGD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=T1D:'>T1D</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Site: <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA].  
2BGD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA].  


==Reference==
==Reference==
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15863305 15863305]
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15863305 15863305]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: protein tyrosine phosphatase]]
[[Category: protein tyrosine phosphatase]]


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