2bgc: Difference between revisions

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[[Image:2bgc.gif|left|200px]]<br /><applet load="2bgc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bgc.gif|left|200px]]
caption="2bgc, resolution 2.30&Aring;" />
 
'''PRFA-G145S, A CONSTITUTIVE ACTIVE MUTANT OF THE TRANSCRIPTIONAL REGULATOR IN L.MONOCYTOGENES'''<br />
{{Structure
|PDB= 2bgc |SIZE=350|CAPTION= <scene name='initialview01'>2bgc</scene>, resolution 2.30&Aring;
|SITE= <scene name='pdbsite=AC1:Dtt+Binding+Site+For+Chain+F'>AC1</scene>
|LIGAND= <scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene> and <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>
|ACTIVITY=
|GENE=
}}
 
'''PRFA-G145S, A CONSTITUTIVE ACTIVE MUTANT OF THE TRANSCRIPTIONAL REGULATOR IN L.MONOCYTOGENES'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BGC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] with <scene name='pdbligand=DTU:'>DTU</scene> and <scene name='pdbligand=DTT:'>DTT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Dtt+Binding+Site+For+Chain+F'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGC OCA].  
2BGC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGC OCA].  


==Reference==
==Reference==
The mutation G145S in PrfA, a key virulence regulator of Listeria monocytogenes, increases DNA-binding affinity by stabilizing the HTH motif., Eiting M, Hageluken G, Schubert WD, Heinz DW, Mol Microbiol. 2005 Apr;56(2):433-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15813735 15813735]
The mutation G145S in PrfA, a key virulence regulator of Listeria monocytogenes, increases DNA-binding affinity by stabilizing the HTH motif., Eiting M, Hageluken G, Schubert WD, Heinz DW, Mol Microbiol. 2005 Apr;56(2):433-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15813735 15813735]
[[Category: Listeria monocytogenes]]
[[Category: Listeria monocytogenes]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transcriptional regulator]]
[[Category: transcriptional regulator]]


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