2bhj: Difference between revisions

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[[Image:2bhj.gif|left|200px]]<br /><applet load="2bhj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bhj.gif|left|200px]]
caption="2bhj, resolution 3.2&Aring;" />
 
'''MURINE INO SYNTHASE WITH COUMARIN INHIBITOR'''<br />
{{Structure
|PDB= 2bhj |SIZE=350|CAPTION= <scene name='initialview01'>2bhj</scene>, resolution 3.2&Aring;
|SITE= <scene name='pdbsite=AC1:Hbl+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=FC1:THIOCOUMARIN'>FC1</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39]
|GENE=
}}
 
'''MURINE INO SYNTHASE WITH COUMARIN INHIBITOR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BHJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=FC1:'>FC1</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=HBI:'>HBI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] Known structural/functional Site: <scene name='pdbsite=AC1:Hbl+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BHJ OCA].  
2BHJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BHJ OCA].  


==Reference==
==Reference==
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase., Jackson SA, Sahni S, Lee L, Luo Y, Nieduzak TR, Liang G, Chiang Y, Collar N, Fink D, He W, Laoui A, Merrill J, Boffey R, Crackett P, Rees B, Wong M, Guilloteau JP, Mathieu M, Rebello SS, Bioorg Med Chem. 2005 Apr 15;13(8):2723-39. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15781384 15781384]
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase., Jackson SA, Sahni S, Lee L, Luo Y, Nieduzak TR, Liang G, Chiang Y, Collar N, Fink D, He W, Laoui A, Merrill J, Boffey R, Crackett P, Rees B, Wong M, Guilloteau JP, Mathieu M, Rebello SS, Bioorg Med Chem. 2005 Apr 15;13(8):2723-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15781384 15781384]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Nitric-oxide synthase]]
[[Category: Nitric-oxide synthase]]
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[[Category: fmn]]
[[Category: fmn]]
[[Category: heme]]
[[Category: heme]]
[[Category: inos]]
[[Category: ino]]
[[Category: metal-binding]]
[[Category: metal-binding]]
[[Category: nadp]]
[[Category: nadp]]
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[[Category: zinc]]
[[Category: zinc]]


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