1aum: Difference between revisions
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==HIV CAPSID C-TERMINAL DOMAIN (CAC146)== | |||
<StructureSection load='1aum' size='340' side='right' caption='[[1aum]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1aum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AUM FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1aum RCSB], [http://www.ebi.ac.uk/pdbsum/1aum PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1. | |||
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.,Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP Science. 1997 Oct 31;278(5339):849-53. PMID:9346481<ref>PMID:9346481</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Virus coat protein|Virus coat protein]] | *[[Virus coat protein|Virus coat protein]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Gamble, T R | [[Category: Gamble, T R]] | ||
[[Category: Hill, C P | [[Category: Hill, C P]] | ||
[[Category: Mccutcheon, J P | [[Category: Mccutcheon, J P]] | ||
[[Category: Schwedler, U K.Von | [[Category: Schwedler, U K.Von]] | ||
[[Category: Sundquist, W I | [[Category: Sundquist, W I]] | ||
[[Category: Vajdos, F F | [[Category: Vajdos, F F]] | ||
[[Category: Wang, H | [[Category: Wang, H]] | ||
[[Category: Worthylake, D K | [[Category: Worthylake, D K]] | ||
[[Category: Yoo, S | [[Category: Yoo, S]] | ||
[[Category: C-terminal domain]] | [[Category: C-terminal domain]] | ||
[[Category: Cac146]] | [[Category: Cac146]] | ||
Revision as of 14:14, 17 December 2014
HIV CAPSID C-TERMINAL DOMAIN (CAC146)
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