3puh: Difference between revisions
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===Cocaine Esterase, wild-type biologically active dimer=== | ===Cocaine Esterase, wild-type biologically active dimer=== | ||
{{ABSTRACT_PUBMED_21890748}} | {{ABSTRACT_PUBMED_21890748}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM]] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3puh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUH OCA]. | [[3puh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp._mb1_'bresler_1999' Rhodococcus sp. mb1 'bresler 1999']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUH OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021890748</ref><references group="xtra"/> | <ref group="xtra">PMID:021890748</ref><references group="xtra"/><references/> | ||
[[Category: Rhodococcus sp.]] | [[Category: Rhodococcus sp. mb1 'bresler 1999']] | ||
[[Category: Nance, M R.]] | [[Category: Nance, M R.]] | ||
[[Category: Tesmer, J J.G.]] | [[Category: Tesmer, J J.G.]] | ||
