Group:SMART:2010 Pingry SMART Team: Difference between revisions
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====PDB ID: 1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)==== | ====PDB ID: 1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)==== | ||
'''Design description''' | '''Design description''' | ||
2,5-DKGR A possesses a parallel alpha-beta structural motif of the <scene name='2010_Pingry_SMART_Team/1a80-default/2'>eight alpha helices (highlighted red) and eight beta strands (highlighted blue)</scene> found in all enzymes in the aldo-keto reductase(AKR) family. | <scene name='2010_Pingry_SMART_Team/1a80-original/22'>2,5-DKGR A</scene> possesses a parallel alpha-beta structural motif of the <scene name='2010_Pingry_SMART_Team/1a80-default/2'>eight alpha helices (highlighted red) and eight beta strands (highlighted blue)</scene> found in all enzymes in the aldo-keto reductase(AKR) family. | ||
The residue <scene name='2010_Pingry_SMART_Team/1a80-original/16'>Tyr50</scene> is found at the bottom of the active-site pocket and is conserved in all members of the AKR family. The catalytic mechanism in 2,5 DKGR A is similar to aldose reductase and other members of that super family. | The residue <scene name='2010_Pingry_SMART_Team/1a80-original/16'>Tyr50</scene> is found at the bottom of the active-site pocket and is conserved in all members of the AKR family. The catalytic mechanism in 2,5 DKGR A is similar to aldose reductase and other members of that super family. | ||
