4isq: Difference between revisions
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{{STRUCTURE_4isq| PDB=4isq | SCENE= }} | |||
===Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | |||
==About this Structure== | |||
[[4isq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA]. | |||
[[Category: Clostridium botulinum]] | |||
[[Category: Berntsson, R P.A.]] | |||
[[Category: Dong, M.]] | |||
[[Category: Peng, L.]] | |||
[[Category: Stenmark, P.]] | |||
[[Category: Svensson, L M.]] | |||
[[Category: Membrane binding]] | |||
[[Category: Synaptotagmin and ganglioside binding]] | |||
[[Category: Toxin]] | |||
Revision as of 07:59, 14 August 2013
Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
Function
[SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
About this Structure
4isq is a 6 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
