4j03: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant===

The ~~entry 4j03 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>

~~Authors~~: ~~Morisseau, C~~.~~, Pakhomova, S~~.~~, Hwang, S~~.~~H., Newcomer, M~~.E.~~, Hammock, B~~.D.

==About this Structure==

[[4j03]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J03 OCA].

~~Description~~: ~~Crystal structure of human soluble epoxide~~ hydrolase ~~complexed with fulvestrant~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Hammock, B D.]]

[[Category: Hwang, S H.]]

[[Category: Morisseau, C.]]

[[Category: Newcomer, M E.]]

[[Category: Pakhomova, S.]]

[[Category: Domain-swapped dimer]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4j03|  PDB=4j03  |  SCENE=  }}
+===Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant===
+{{ABSTRACT_PUBMED_23684894}}
-The entry 4j03 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
-Authors: Morisseau, C., Pakhomova, S., Hwang, S.H., Newcomer, M.E., Hammock, B.D.
+==About this Structure==
+[[4j03]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J03 OCA].
-Description: Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant
+==Reference==
+<ref group="xtra">PMID:023684894</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Hammock, B D.]]
+[[Category: Hwang, S H.]]
+[[Category: Morisseau, C.]]
+[[Category: Newcomer, M E.]]
+[[Category: Pakhomova, S.]]
+[[Category: Domain-swapped dimer]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]