4jaa: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)LEU peptide===

~~The entry 4jaa is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/HIF1N_HUMAN HIF1N_HUMAN]] Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.<ref>PMID:12080085</ref> <ref>PMID:12042299</ref> <ref>PMID:17003112</ref> <ref>PMID:18299578</ref> <ref>PMID:19245366</ref> <ref>PMID:17573339</ref> <ref>PMID:21251231</ref> <ref>PMID:21177872</ref>

~~Authors~~: ~~Scotti, J.S., Ge, W., McDonough, M~~.A.~~, Schofield, C~~.J.

==About this Structure==

[[4jaa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAA OCA].

~~Description~~: ~~Structure of an oxygenase in~~ complex ~~with substrate~~

==Reference==

[[Category: Hypoxia-inducible factor-asparagine dioxygenase]]

[[Category: Ge, W.]]

[[Category: McDonough, M A.]]

[[Category: Schofield, C J.]]

[[Category: Scotti, J S.]]

[[Category: 2-oxoglutarate]]

[[Category: Activator/inhibitor]]

[[Category: Ard]]

[[Category: Asparaginyl]]

[[Category: Aspartyl hydroxylase]]

[[Category: Beta-hydroxylation]]

[[Category: Dioxygenase]]

[[Category: Dna-binding]]

[[Category: Dsbh]]

[[Category: Epigenetic regulation]]

[[Category: Facial triad]]

[[Category: Helix-loop-helix-beta]]

[[Category: Metal-binding]]

[[Category: Non-heme]]

[[Category: Oxidoreductase-peptide complex]]

[[Category: Oxygenase]]

[[Category: Signaling]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jaa|  PDB=4jaa  |  SCENE=  }}
+===Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)LEU peptide===
-The entry 4jaa is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/HIF1N_HUMAN HIF1N_HUMAN]] Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.<ref>PMID:12080085</ref> <ref>PMID:12042299</ref> <ref>PMID:17003112</ref> <ref>PMID:18299578</ref> <ref>PMID:19245366</ref> <ref>PMID:17573339</ref> <ref>PMID:21251231</ref> <ref>PMID:21177872</ref>
-Authors: Scotti, J.S., Ge, W., McDonough, M.A., Schofield, C.J.
+==About this Structure==
+[[4jaa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAA OCA].
-Description: Structure of an oxygenase in complex with substrate
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Hypoxia-inducible factor-asparagine dioxygenase]]
+[[Category: Ge, W.]]
+[[Category: McDonough, M A.]]
+[[Category: Schofield, C J.]]
+[[Category: Scotti, J S.]]
+[[Category: 2-oxoglutarate]]
+[[Category: Activator/inhibitor]]
+[[Category: Ard]]
+[[Category: Asparaginyl]]
+[[Category: Aspartyl hydroxylase]]
+[[Category: Beta-hydroxylation]]
+[[Category: Dioxygenase]]
+[[Category: Dna-binding]]
+[[Category: Dsbh]]
+[[Category: Epigenetic regulation]]
+[[Category: Facial triad]]
+[[Category: Helix-loop-helix-beta]]
+[[Category: Metal-binding]]
+[[Category: Non-heme]]
+[[Category: Oxidoreductase-peptide complex]]
+[[Category: Oxygenase]]
+[[Category: Signaling]]
+[[Category: Transcription]]