1n72: Difference between revisions
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===Structure and Ligand of a Histone Acetyltransferase Bromodomain=== | ===Structure and Ligand of a Histone Acetyltransferase Bromodomain=== | ||
{{ABSTRACT_PUBMED_10365964}} | {{ABSTRACT_PUBMED_10365964}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/PCAF_HUMAN PCAF_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref><ref>PMID:9707565</ref><ref>PMID:10675335</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:010365964</ref><references group="xtra"/> | <ref group="xtra">PMID:010365964</ref><references group="xtra"/><references/> | ||
[[Category: Histone acetyltransferase]] | [[Category: Histone acetyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
