4bel: Difference between revisions
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{{STRUCTURE_4bel| PDB=4bel | SCENE= }} | |||
===BACE2 XAPERONE COMPLEX=== | |||
{{ABSTRACT_PUBMED_23695257}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref> | |||
==About this Structure== | |||
[[4bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEL OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023695257</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Lama glama]] | |||
[[Category: Memapsin 1]] | |||
[[Category: Banner, D W.]] | |||
[[Category: Benz, J.]] | |||
[[Category: Kuglstatter, A.]] | |||
[[Category: Ruf, A.]] | |||
[[Category: Stihle, M.]] | |||
[[Category: Hydrolase-immune system complex]] | |||
[[Category: Nanobody]] | |||