4bey: Difference between revisions
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{{STRUCTURE_4bey| PDB=4bey | SCENE= }} | |||
===Night blindness causing G90D rhodopsin in complex with GaCT2 peptide=== | |||
{{ABSTRACT_PUBMED_23579341}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. | |||
==About this Structure== | |||
[[4bey]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEY OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Bos taurus]] | |||
[[Category: Deupi, X.]] | |||
[[Category: Gurevich, V V.]] | |||
[[Category: Homan, K T.]] | |||
[[Category: Ostermaier, M K.]] | |||
[[Category: Panneels, V.]] | |||
[[Category: Schertler, G F.X.]] | |||
[[Category: Singhal, A.]] | |||
[[Category: Standfuss, J.]] | |||
[[Category: Tesmer, J J.G.]] | |||
[[Category: Veprintsev, D.]] | |||
[[Category: Vishnivetskiy, S A.]] | |||
[[Category: Active state]] | |||
[[Category: Congential stationary night blindness]] | |||
[[Category: Disease mutant]] | |||
[[Category: Gpcr]] | |||
[[Category: Membrane protein]] | |||
Revision as of 07:44, 8 May 2013
Night blindness causing G90D rhodopsin in complex with GaCT2 peptide
Template:ABSTRACT PUBMED 23579341
Function
[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2] [GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
About this Structure
4bey is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
- ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
- ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
