4ht1: Difference between revisions
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{{STRUCTURE_4ht1| PDB=4ht1 | SCENE= }} | |||
===Human TWEAK in complex with the Fab fragment of a neutralizing antibody=== | |||
{{ABSTRACT_PUBMED_23667509}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TNF12_HUMAN TNF12_HUMAN]] Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.<ref>PMID:10085077</ref> | |||
==About this Structure== | |||
[[4ht1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HT1 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023667509</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Lammens, A.]] | |||
[[Category: Antibody fab]] | |||
[[Category: Cytokine]] | |||
[[Category: Extracellular thd domain]] | |||
[[Category: Immune system]] | |||
[[Category: Membrane bound]] | |||
[[Category: Tnf homology domain]] | |||
[[Category: Tweak receptor]] | |||
Revision as of 15:37, 19 June 2013
Human TWEAK in complex with the Fab fragment of a neutralizing antibody
Template:ABSTRACT PUBMED 23667509
Function
[TNF12_HUMAN] Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.[1]
About this Structure
4ht1 is a 3 chain structure with sequence from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
- Lammens A, Baehner M, Kohnert U, Niewoehner J, von Proff L, Schraeml M, Lammens K, Hopfner KP. Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. PLoS One. 2013 May 8;8(5):e62697. doi: 10.1371/journal.pone.0062697. Print 2013. PMID:23667509 doi:10.1371/journal.pone.0062697
