4jaz: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the complex between PPARgamma LBD and trans-resveratrol===

~~The~~ entry ~~4jaz~~ is ~~ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[http://omim.org/entry/604367 604367]]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[http://omim.org/entry/137800 137800]]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.

~~Authors~~: ~~Pochetti, G~~.~~, Capelli, D~~., ~~Montanari, R~~.~~, Calleri, E~~.~~, Moaddel, R~~.~~, Temporini, C~~.

==Function==

[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>

~~Description~~: ~~Crystal structure~~ of ~~the complex between PPARgamma LBD and trans~~-~~resveratrol~~

==About this Structure==

[[4jaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAZ OCA].

==Reference==

[[Category: Calleri, E.]]

[[Category: Capelli, D.]]

[[Category: Moaddel, R.]]

[[Category: Montanari, R.]]

[[Category: Pochetti, G.]]

[[Category: Temporini, C.]]

[[Category: Activator]]

[[Category: Bundle of alpha-helice]]

[[Category: Diabetes mellitus]]

[[Category: Disease mutation]]

[[Category: Dna-binding]]

[[Category: Nucleus]]

[[Category: Obesity]]

[[Category: Phosphorylation]]

[[Category: Receptor]]

[[Category: Small four-strnded beta-sheet]]

[[Category: Transcription]]

[[Category: Transcription regulation]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jaz|  PDB=4jaz  |  SCENE=  }}
+===Crystal structure of the complex between PPARgamma LBD and trans-resveratrol===
-The entry 4jaz is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.  Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref>   Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[http://omim.org/entry/604367 604367]]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref>   Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[http://omim.org/entry/137800 137800]]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
-Authors: Pochetti, G., Capelli, D., Montanari, R., Calleri, E., Moaddel, R., Temporini, C.
+==Function==
+[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
-Description: Crystal structure of the complex between PPARgamma LBD and trans-resveratrol
+==About this Structure==
+[[4jaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAZ OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Calleri, E.]]
+[[Category: Capelli, D.]]
+[[Category: Moaddel, R.]]
+[[Category: Montanari, R.]]
+[[Category: Pochetti, G.]]
+[[Category: Temporini, C.]]
+[[Category: Activator]]
+[[Category: Bundle of alpha-helice]]
+[[Category: Diabetes mellitus]]
+[[Category: Disease mutation]]
+[[Category: Dna-binding]]
+[[Category: Nucleus]]
+[[Category: Obesity]]
+[[Category: Phosphorylation]]
+[[Category: Receptor]]
+[[Category: Small four-strnded beta-sheet]]
+[[Category: Transcription]]
+[[Category: Transcription regulation]]