4jds: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine===

~~The entry 4jds is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref><ref>PMID:15099517</ref><ref>PMID:16141209</ref><ref>PMID:17108971</ref><ref>PMID:12540855</ref><ref>PMID:15525938</ref>

~~Authors~~: ~~Dong, A~~.~~, Wu, H~~.~~, Zeng, H~~.~~, Park, H., Elbakkouri, M., Barsyte, D., Vedadi, M., Tatlock, J., Owev, D., Bunnage, M., Bountra, C., Arrowsmith, C.H., Edwards, A~~.M.~~, Brown, P~~.J.~~, Structural Genomics Consortium (SGC)~~

==About this Structure==

[[4jds]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDS OCA].

~~Description~~: ~~SETD7 in complex with inhibitor PF~~-5426 ~~and~~ S-adenosyl-methionine

==Reference==

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

[[Category: Bakkouri, M El.]]

[[Category: Barsyte, D.]]

[[Category: Bountra, C.]]

[[Category: Brown, P J.]]

[[Category: Bunnage, M.]]

[[Category: Dong, A.]]

[[Category: Edwards, A M.]]

[[Category: Owen, D.]]

[[Category: Park, H.]]

[[Category: SGC, Structural Genomics Consortium.]]

[[Category: Tatlock, J.]]

[[Category: Vedadi, M.]]

[[Category: Wu, H.]]

[[Category: Zeng, H.]]

[[Category: Histone lysine methyltransferase]]

[[Category: Histone modification]]

[[Category: Inhibitor]]

[[Category: Methyltransferase]]

[[Category: Pf-5426]]

[[Category: S-adenosyl-l-methionine]]

[[Category: Sam]]

[[Category: Set domain]]

[[Category: Setd7]]

[[Category: Sgc]]

[[Category: Structural genomics consortium]]

[[Category: Transcription regulation]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jds|  PDB=4jds  |  SCENE=  }}
+===SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine===
-The entry 4jds is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref><ref>PMID:15099517</ref><ref>PMID:16141209</ref><ref>PMID:17108971</ref><ref>PMID:12540855</ref><ref>PMID:15525938</ref>
-Authors: Dong, A., Wu, H., Zeng, H., Park, H., Elbakkouri, M., Barsyte, D., Vedadi, M., Tatlock, J., Owev, D., Bunnage, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
+==About this Structure==
+[[4jds]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDS OCA].
-Description: SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Homo sapiens]]
+[[Category: Arrowsmith, C H.]]
+[[Category: Bakkouri, M El.]]
+[[Category: Barsyte, D.]]
+[[Category: Bountra, C.]]
+[[Category: Brown, P J.]]
+[[Category: Bunnage, M.]]
+[[Category: Dong, A.]]
+[[Category: Edwards, A M.]]
+[[Category: Owen, D.]]
+[[Category: Park, H.]]
+[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Tatlock, J.]]
+[[Category: Vedadi, M.]]
+[[Category: Wu, H.]]
+[[Category: Zeng, H.]]
+[[Category: Histone lysine methyltransferase]]
+[[Category: Histone modification]]
+[[Category: Inhibitor]]
+[[Category: Methyltransferase]]
+[[Category: Pf-5426]]
+[[Category: S-adenosyl-l-methionine]]
+[[Category: Sam]]
+[[Category: Set domain]]
+[[Category: Setd7]]
+[[Category: Sgc]]
+[[Category: Structural genomics consortium]]
+[[Category: Transcription regulation]]
+[[Category: Transferase-transferase inhibitor complex]]