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'''Unreleased structure'''
{{STRUCTURE_4jjh|  PDB=4jjh  |  SCENE=  }}
===Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624]===


The entry 4jjh is ON HOLD
==Disease==
[[http://www.uniprot.org/uniprot/PVRL4_HUMAN PVRL4_HUMAN]] Ectodermal dysplasia - syndactyly syndrome. Defects in PVRL4 are the cause of ectodermal dysplasia-syndactyly syndrome type 1 (EDSS1) [MIM:[http://omim.org/entry/613573 613573]]. EDSS1 is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.<ref>PMID:20691405</ref>


Authors: Kumar, P.R., Bonanno, J., Ahmed, M., Banu, R., Bhosle, R., Calarese, D., Celikigil, A., Chamala, S., Chan, M.K., Chowdhury, S., Fiser, A., Garforth, S., Glenn, A.S., Hillerich, B., Khafizov, K., Love, J., Patel, H., Seidel, R., Stead, M., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
==Function==
[[http://www.uniprot.org/uniprot/PVRL4_HUMAN PVRL4_HUMAN]] Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.  


Description: Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624]
==About this Structure==
[[4jjh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJH OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Ahmed, M.]]
[[Category: Almo, S C.]]
[[Category: Banu, R.]]
[[Category: Bhosle, R.]]
[[Category: Bonanno, J.]]
[[Category: Calarese, D.]]
[[Category: Celikigil, A.]]
[[Category: Chamala, S.]]
[[Category: Chan, M K.]]
[[Category: Chowdhury, S.]]
[[Category: Fiser, A.]]
[[Category: Garforth, S.]]
[[Category: Glenn, A S.]]
[[Category: Hillerich, B.]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
[[Category: Khafizov, K.]]
[[Category: Kumar, P R.]]
[[Category: Love, J.]]
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
[[Category: Nathenson, S G.]]
[[Category: Patel, H.]]
[[Category: Seidel, R.]]
[[Category: Stead, M.]]
[[Category: Toro, R.]]
[[Category: Atoms-to-animals: the immune function network]]
[[Category: Cell adhesion]]
[[Category: Ifn]]
[[Category: Ig superfamily]]
[[Category: Ig-like d1 domain]]
[[Category: Immune system]]
[[Category: Nectin-4]]
[[Category: New york structural genomics research consortium]]
[[Category: Nysgrc]]
[[Category: Psi]]
[[Category: Structural genomic]]
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