2bz5: Difference between revisions

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[[Image:2bz5.gif|left|200px]]<br /><applet load="2bz5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2bz5.gif|left|200px]]
caption="2bz5, resolution 1.90&Aring;" />
 
'''STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS'''<br />
{{Structure
|PDB= 2bz5 |SIZE=350|CAPTION= <scene name='initialview01'>2bz5</scene>, resolution 1.90&Aring;
|SITE= <scene name='pdbsite=AC1:Ab4+Binding+Site+For+Chain+B'>AC1</scene>
|LIGAND= <scene name='pdbligand=AB4:2,5-DICHLORO-N-[4-HYDROXY-3-(2-HYDROXY-1-NAPHTHYL)PHENYL]BENZENESULFONAMIDE'>AB4</scene>
|ACTIVITY=
|GENE=
}}
 
'''STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2BZ5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AB4:'>AB4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ab4+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ5 OCA].  
2BZ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ5 OCA].  


==Reference==
==Reference==
Structure-based discovery of a new class of Hsp90 inhibitors., Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5187-91. Epub 2005 Oct 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16202589 16202589]
Structure-based discovery of a new class of Hsp90 inhibitors., Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5187-91. Epub 2005 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16202589 16202589]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: phosphorylation]]
[[Category: phosphorylation]]


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