2c5v: Difference between revisions

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[[Image:2c5v.gif|left|200px]]<br /><applet load="2c5v" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2c5v.gif|left|200px]]
caption="2c5v, resolution 2.90&Aring;" />
 
'''DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN'''<br />
{{Structure
|PDB= 2c5v |SIZE=350|CAPTION= <scene name='initialview01'>2c5v</scene>, resolution 2.90&Aring;
|SITE= <scene name='pdbsite=AC1:Nh2+Binding+Site+For+Chain+H'>AC1</scene>
|LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> and <scene name='pdbligand=CK4:4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>CK4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]
|GENE=
}}
 
'''DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2C5V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NH2:'>NH2</scene> and <scene name='pdbligand=CK4:'>CK4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1OKU. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=AC1:Nh2+Binding+Site+For+Chain+H'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5V OCA].  
2C5V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1OKU. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5V OCA].  


==Reference==
==Reference==
Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design., Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM, Chem Biol. 2006 Feb;13(2):201-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16492568 16492568]
Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design., Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM, Chem Biol. 2006 Feb;13(2):201-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16492568 16492568]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: complex (kinase/cyclin)]]
[[Category: complex (kinase/cyclin)]]
[[Category: complex (transferase/cyclin)]]
[[Category: complex (transferase/cyclin)]]
[[Category: cycin a]]
[[Category: cycin some]]
[[Category: cyclin]]
[[Category: cyclin]]
[[Category: drug design]]
[[Category: drug design]]
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[[Category: transferase]]
[[Category: transferase]]


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