2bxe: Difference between revisions
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{{STRUCTURE_2bxe| PDB=2bxe | SCENE= }} | {{STRUCTURE_2bxe| PDB=2bxe | SCENE= }} | ||
=== | ===Human serum albumin complexed with diflunisal=== | ||
{{ABSTRACT_PUBMED_16169013}} | {{ABSTRACT_PUBMED_16169013}} | ||
==Disease== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref> | [[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | ||
==Function== | ==Function== | ||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | [[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Petitpas, I.]] | [[Category: Petitpas, I.]] | ||
[[Category: Zunszain, P A.]] | [[Category: Zunszain, P A.]] | ||
[[Category: Carrier protein]] | [[Category: Carrier protein]] | ||
[[Category: Drug-binding]] | [[Category: Drug-binding]] | ||
[[Category: Lipid-binding]] | [[Category: Lipid-binding]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
