3l9j: Difference between revisions
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==Function== | ==Function== | ||
[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref> | [[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref> The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3l9j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3l9j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9J OCA]. | ||
==See Also== | |||
*[[Tumor necrosis factor|Tumor necrosis factor]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020179326</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:020179326</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Andersen, M H.]] | [[Category: Andersen, M H.]] | ||
[[Category: Byla, P.]] | [[Category: Byla, P.]] | ||
