2cel: Difference between revisions

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[[Image:2cel.jpg|left|200px]]<br /><applet load="2cel" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2cel.jpg|left|200px]]
caption="2cel, resolution 2.0&Aring;" />
 
'''ACTIVE-SITE MUTANT E212Q DETERMINED AT PH 6.0 WITH NO LIGAND BOUND IN THE ACTIVE SITE'''<br />
{{Structure
|PDB= 2cel |SIZE=350|CAPTION= <scene name='initialview01'>2cel</scene>, resolution 2.0&Aring;
|SITE= <scene name='pdbsite=CAA:Ca-Binding+Site+On+Non-Crystallographic+Dyad.+Note+That+...'>CAA</scene>, <scene name='pdbsite=CAB:Ca-Binding+Site+On+Non-Crystallographic+Dyad.+Note+That+...'>CAB</scene>, <scene name='pdbsite=CTA:Catalytic+Site+Including+The+E212q+Mutation'>CTA</scene> and <scene name='pdbsite=CTB:Catalytic+Site+Including+The+E212q+Mutation'>CTB</scene>
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91]
|GENE= CBH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=51453 Hypocrea jecorina])
}}
 
'''ACTIVE-SITE MUTANT E212Q DETERMINED AT PH 6.0 WITH NO LIGAND BOUND IN THE ACTIVE SITE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2CEL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] Known structural/functional Sites: <scene name='pdbsite=CAA:Ca-Binding+Site+On+Non-Crystallographic+Dyad.+Note+That+...'>CAA</scene>, <scene name='pdbsite=CAB:Ca-Binding+Site+On+Non-Crystallographic+Dyad.+Note+That+...'>CAB</scene>, <scene name='pdbsite=CTA:Catalytic+Site+Including+The+E212q+Mutation'>CTA</scene> and <scene name='pdbsite=CTB:Catalytic+Site+Including+The+E212q+Mutation'>CTB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEL OCA].  
2CEL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEL OCA].  


==Reference==
==Reference==
Activity studies and crystal structures of catalytically deficient mutants of cellobiohydrolase I from Trichoderma reesei., Stahlberg J, Divne C, Koivula A, Piens K, Claeyssens M, Teeri TT, Jones TA, J Mol Biol. 1996 Nov 29;264(2):337-49. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8951380 8951380]
Activity studies and crystal structures of catalytically deficient mutants of cellobiohydrolase I from Trichoderma reesei., Stahlberg J, Divne C, Koivula A, Piens K, Claeyssens M, Teeri TT, Jones TA, J Mol Biol. 1996 Nov 29;264(2):337-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8951380 8951380]
[[Category: Cellulose 1,4-beta-cellobiosidase]]
[[Category: Cellulose 1,4-beta-cellobiosidase]]
[[Category: Hypocrea jecorina]]
[[Category: Hypocrea jecorina]]
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[[Category: hydrolase]]
[[Category: hydrolase]]


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