1psl: Difference between revisions
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==COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN== | |||
<StructureSection load='1psl' size='340' side='right' caption='[[1psl]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSL FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psl FirstGlance], [http://www.ebi.ac.uk/pdbsum/1psl PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Structural and environmental constraints greatly simplify the folding problem for membrane proteins. Computational methods can be used in a global search to find a small number of chemically reasonable models within these constraints, such that a modest set of experimental data can distinguish among them. We show that, for phospholamban, the global search can be further simplified by reducing the problem to two-body, rather than many-body, interactions. This method of a constrained global search combined with experimental mutagenesis data yields a three-dimensional structure for this pentameric ion channel. The model is a left-handed symmetric homopentamer of alpha-helices with a well-defined channel, lined solely by hydrophobic residues. | |||
Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban.,Adams PD, Arkin IT, Engelman DM, Brunger AT Nat Struct Biol. 1995 Feb;2(2):154-62. PMID:7749920<ref>PMID:7749920</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Adams, P D]] | [[Category: Adams, P D]] | ||
[[Category: Arkin, I T]] | [[Category: Arkin, I T]] | ||
[[Category: Brunger, A T]] | [[Category: Brunger, A T]] | ||
[[Category: Engelman, D M]] | [[Category: Engelman, D M]] | ||
Revision as of 11:58, 18 December 2014
COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN
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