2cxv: Difference between revisions

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[[Image:2cxv.gif|left|200px]]<br /><applet load="2cxv" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2cxv.gif|left|200px]]
caption="2cxv, resolution 1.40&Aring;" />
 
'''Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-Derived betaLactone: Selective Crystallization and High-resolution Structure of the His-102 Adduct'''<br />
{{Structure
|PDB= 2cxv |SIZE=350|CAPTION= <scene name='initialview01'>2cxv</scene>, resolution 1.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=BBL:N-[(BENZYLOXY)CARBONYL]-L-ALANINE'>BBL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Picornain_3C Picornain 3C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.28 3.4.22.28]
|GENE= 3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12092 Hepatitis A virus])
}}
 
'''Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-Derived betaLactone: Selective Crystallization and High-resolution Structure of the His-102 Adduct'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2CXV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus] with <scene name='pdbligand=BBL:'>BBL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Picornain_3C Picornain 3C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.28 3.4.22.28] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXV OCA].  
2CXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXV OCA].  


==Reference==
==Reference==
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site., Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN, J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16288920 16288920]
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site., Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN, J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16288920 16288920]
[[Category: Hepatitis a virus]]
[[Category: Hepatitis a virus]]
[[Category: Picornain 3C]]
[[Category: Picornain 3C]]
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[[Category: beta-lactone]]
[[Category: beta-lactone]]
[[Category: cysteine protease]]
[[Category: cysteine protease]]
[[Category: hepatitis a]]
[[Category: hepatitis some]]
[[Category: inhibitor]]
[[Category: inhibitor]]
[[Category: picornavirus]]
[[Category: picornavirus]]


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