2d3u: Difference between revisions

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[[Image:2d3u.gif|left|200px]]<br /><applet load="2d3u" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2d3u.gif|left|200px]]
caption="2d3u, resolution 2.00&Aring;" />
 
'''X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor'''<br />
{{Structure
|PDB= 2d3u |SIZE=350|CAPTION= <scene name='initialview01'>2d3u</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CCT:5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID'>CCT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
|GENE= Type 1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
}}
 
'''X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2D3U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=CCT:'>CCT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3U OCA].  
2D3U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3U OCA].  


==Reference==
==Reference==
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition., Biswal BK, Wang M, Cherney MM, Chan L, Yannopoulos CG, Bilimoria D, Bedard J, James MN, J Mol Biol. 2006 Aug 4;361(1):33-45. Epub 2006 Jun 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16828488 16828488]
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition., Biswal BK, Wang M, Cherney MM, Chan L, Yannopoulos CG, Bilimoria D, Bedard J, James MN, J Mol Biol. 2006 Aug 4;361(1):33-45. Epub 2006 Jun 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16828488 16828488]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: x-ray crystallography]]
[[Category: x-ray crystallography]]


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