2d4z: Difference between revisions
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'''Crystal structure of the cytoplasmic domain of the chloride channel ClC-0''' | {{Structure | ||
|PDB= 2d4z |SIZE=350|CAPTION= <scene name='initialview01'>2d4z</scene>, resolution 3.10Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
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'''Crystal structure of the cytoplasmic domain of the chloride channel ClC-0''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2D4Z is a [ | 2D4Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_marmorata Torpedo marmorata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4Z OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the cytoplasmic domain of the chloride channel ClC-0., Meyer S, Dutzler R, Structure. 2006 Feb;14(2):299-307. PMID:[http:// | Crystal structure of the cytoplasmic domain of the chloride channel ClC-0., Meyer S, Dutzler R, Structure. 2006 Feb;14(2):299-307. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16472749 16472749] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Torpedo marmorata]] | [[Category: Torpedo marmorata]] | ||
[[Category: Dutzler, R.]] | [[Category: Dutzler, R.]] | ||
[[Category: Meyer, S.]] | [[Category: Meyer, S.]] | ||
[[Category: cbs | [[Category: cbs domain]] | ||
[[Category: clc chloride channel cytoplasmic domain]] | [[Category: clc chloride channel cytoplasmic domain]] | ||
[[Category: ion channel regulatory subunit]] | [[Category: ion channel regulatory subunit]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:23:22 2008'' | ||
Revision as of 14:23, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of the cytoplasmic domain of the chloride channel ClC-0
Overview
Ion channels are frequently organized in a modular fashion and consist of a membrane-embedded pore domain and a soluble regulatory domain. A similar organization is found for the ClC family of Cl- channels and transporters. Here, we describe the crystal structure of the cytoplasmic domain of ClC-0, the voltage-dependent Cl- channel from T. marmorata. The structure contains a folded core of two tightly interacting cystathionine beta-synthetase (CBS) subdomains. The two subdomains are connected by a 96 residue mobile linker that is disordered in the crystals. As revealed by analytical ultracentrifugation, the domains form dimers, thereby most likely extending the 2-fold symmetry of the transmembrane pore. The structure provides insight into the organization of the cytoplasmic domains within the ClC family and establishes a framework for guiding future investigations on regulatory mechanisms.
About this Structure
2D4Z is a Single protein structure of sequence from Torpedo marmorata. Full crystallographic information is available from OCA.
Reference
Crystal structure of the cytoplasmic domain of the chloride channel ClC-0., Meyer S, Dutzler R, Structure. 2006 Feb;14(2):299-307. PMID:16472749
Page seeded by OCA on Thu Mar 20 16:23:22 2008
