Sandbox Reserved 595: Difference between revisions
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Apolipoprotein E is a member of the apolipoprotein family. This soluble protein is produced primarily in the liver and brain; and it is located principally in the plasma and in the central nervous system (CNS) (AA). The systemic transport of cholesterol and other lipids is this protein's main role in the body (W). One minor function it may exhibit is that of immune regulation (W). ApoE may also play a role in synaptic integrity and plasticity (R). Particular isoforms, ε2 and ε4 are implicated in hyperlipoproteinemia (HLP III) and late onset Alzheimer's disease (LOAD). | Apolipoprotein E is a member of the apolipoprotein family. This soluble protein is produced primarily in the liver and brain; and it is located principally in the plasma and in the central nervous system (CNS) (AA). The systemic transport of cholesterol and other lipids is this protein's main role in the body (W). One minor function it may exhibit is that of immune regulation (W). ApoE may also play a role in synaptic integrity and plasticity (R). Particular isoforms, ε2 and ε4 are implicated in hyperlipoproteinemia (HLP III) and late onset Alzheimer's disease (LOAD). | ||
=Structure= | =Structure= | ||
<Structure load='1NFN' size='500' frame='true' align='right' caption=' | <Structure load='1NFN' size='500' frame='true' align='right' caption='3-D Rendering of ApoE3' scene='Insert optional scene name here' /> | ||
==Primary Structural Features== | ==Primary Structural Features== | ||
Apolipoprotein E is a polymorphic glycoprotein that consists of 299 amino acids (A,F). It has a molecular weight of 34kDa (G). The primary structure for ApoE is rich in the amino acid argine (W). | Apolipoprotein E is a polymorphic glycoprotein that consists of 299 amino acids (A,F). It has a molecular weight of 34kDa (G). The primary structure for ApoE is rich in the amino acid argine (W). | ||
