4jgv: Difference between revisions
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{{STRUCTURE_4jgv| PDB=4jgv | SCENE= }} | |||
===Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref> | |||
==About this Structure== | |||
[[4jgv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGV OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Chen, H.]] | |||
[[Category: Li, A.]] | |||
[[Category: Li, F.]] | |||
[[Category: Lin, T.]] | |||
[[Category: Tian, X.]] | |||
[[Category: Wan, W.]] | |||
[[Category: Wan, Y.]] | |||
[[Category: Wu, Q.]] | |||
[[Category: Xing, Y.]] | |||
[[Category: Zhang, Q.]] | |||
[[Category: Transcription]] | |||
Revision as of 10:38, 18 December 2013
Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN
Function
[NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.[1]
About this Structure
4jgv is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Harant H, Lindley IJ. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Res. 2004 Oct 5;32(17):5280-90. Print 2004. PMID:15466594 doi:10.1093/nar/gkh856
