4jqa: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4jqa|  PDB=4jqa  |  SCENE=  }}
===AKR1C2 complex with mefenamic acid===


The entry 4jqa is ON HOLD until Paper Publication
==Disease==
[[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Defects in AKR1C2 are a cause of 46,XY sex reversal type 8 (SRXY8) [MIM:[http://omim.org/entry/614279 614279]]. A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.<ref>PMID:21802064</ref>  


Authors: Yosaatmadja, Y., Flanagan, J.U., Squire, C.J.
==Function==
[[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.<ref>PMID:8573067</ref> 


Description: AKR1C2 complex with mefenamic acid
==About this Structure==
[[4jqa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQA OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Flanagan, J U.]]
[[Category: Squire, C J.]]
[[Category: Yosaatmadja, Y.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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