4e01: Difference between revisions

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{{STRUCTURE_4e01|  PDB=4e01  |  SCENE=  }}
==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP==
===Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP===
<StructureSection load='4e01' size='340' side='right' caption='[[4e01]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4e01]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E01 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0F1:3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>0F1</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tz0|3tz0]], [[3tz2|3tz2]], [[3tz4|3tz4]], [[3tz5|3tz5]], [[4dzy|4dzy]], [[4e00|4e00]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bckdk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e01 RCSB], [http://www.ebi.ac.uk/pdbsum/4e01 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.  
[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.  
 
__TOC__
==About this Structure==
</StructureSection>
[[4e01]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E01 OCA].
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Chuang, D T.]]
[[Category: Chuang, D T]]
[[Category: Chuang, J L.]]
[[Category: Chuang, J L]]
[[Category: Gui, W J.]]
[[Category: Gui, W J]]
[[Category: Li, J.]]
[[Category: Li, J]]
[[Category: Tso, S C.]]
[[Category: Tso, S C]]
[[Category: Wynn, R M.]]
[[Category: Wynn, R M]]
[[Category: Allosteric kinase inhibitor]]
[[Category: Allosteric kinase inhibitor]]
[[Category: Bergerat nucleotide-binding fold]]
[[Category: Bergerat nucleotide-binding fold]]

Revision as of 19:12, 25 December 2014

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP

4e01, resolution 1.97Å

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