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{{STRUCTURE_4eno| PDB=4eno | SCENE= }}
==Crystal structure of oxidized human nm23-H1==
===Crystal structure of oxidized human nm23-H1===
<StructureSection load='4eno' size='340' side='right' caption='[[4eno]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4eno]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ENO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NME1, NDPKA, NM23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eno OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eno RCSB], [http://www.ebi.ac.uk/pdbsum/4eno PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/NDKA_HUMAN NDKA_HUMAN]] Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.<ref>PMID:2056128</ref><ref>PMID:8810265</ref><ref>PMID:12628186</ref>
*[[Nucleoside diphosphate kinase|Nucleoside diphosphate kinase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4eno]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENO OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nucleoside-diphosphate kinase]]
[[Category: Nucleoside-diphosphate kinase]]
[[Category: Kim, M S.]]
[[Category: Kim, M S]]
[[Category: Shin, D H.]]
[[Category: Shin, D H]]
[[Category: Beta protein]]
[[Category: Beta protein]]
[[Category: Ferredoxin-like/alpha]]
[[Category: Ferredoxin-like/alpha]]
[[Category: Nucleoside diphosphate kinase]]
[[Category: Nucleoside diphosphate kinase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 11:04, 21 December 2014

Crystal structure of oxidized human nm23-H1

4eno, resolution 2.80Å

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