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{{STRUCTURE_3jwp|  PDB=3jwp  |  SCENE=  }}
==Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP==
===Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP===
<StructureSection load='3jwp' size='340' side='right' caption='[[3jwp]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3jwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JWP FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/Q8IE47_PLAF7 Q8IE47_PLAF7]] NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.<ref>PMID:15820676</ref><ref>PMID:17827348</ref><ref>PMID:18729382</ref><ref>PMID:18397290</ref><ref>PMID:18525026</ref><ref>PMID:18221799</ref><ref>PMID:19402747</ref><ref>PMID:20601220</ref>  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
==About this Structure==
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF13_0152, Sir2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
[[3jwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWP OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jwp RCSB], [http://www.ebi.ac.uk/pdbsum/3jwp PDBsum]</span></td></tr>
 
</table>
==Reference==
== Evolutionary Conservation ==
<references group="xtra"/><references/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Allali-Hassanali, A.]]
[[Category: Allali-Hassanali, A]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Brand, V.]]
[[Category: Brand, V]]
[[Category: Cossar, D.]]
[[Category: Cossar, D]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Hui, R.]]
[[Category: Hui, R]]
[[Category: Hutchinson, A.]]
[[Category: Hutchinson, A]]
[[Category: Kozieradzki, I.]]
[[Category: Kozieradzki, I]]
[[Category: Lin, Y H.]]
[[Category: Lin, Y H]]
[[Category: MacKenzie, F.]]
[[Category: MacKenzie, F]]
[[Category: Qiu, W.]]
[[Category: Qiu, W]]
[[Category: Ravichandran, M.]]
[[Category: Ravichandran, M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Schapira, M.]]
[[Category: Schapira, M]]
[[Category: Senisterra, G.]]
[[Category: Senisterra, G]]
[[Category: Vedadi, M.]]
[[Category: Vedadi, M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Wernimont, A K.]]
[[Category: Wernimont, A K]]
[[Category: Zhao, Y.]]
[[Category: Zhao, Y]]
[[Category: Malaria]]
[[Category: Malaria]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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