3juz: Difference between revisions

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~~{{STRUCTURE_3juz| PDB=3juz | SCENE= }}~~

==Crystal structure of a mutant of RelB dimerization domain(M5)==

===Crystal structure of a mutant of RelB dimerization domain(M5)===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUZ FirstGlance].

[[~~http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE~~]] ~~NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation~~, ~~immunity, differentiation, cell growth, tumorigenesis and apoptosis~~. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">RelB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>

==~~About this Structure~~==

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [http://www.ebi.ac.uk/pdbsum/3juz PDBsum]</td></tr>

[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA].

</table>

__TOC__

==~~Reference~~==

</StructureSection>

<~~references group~~="~~xtra~~"/><~~references~~/>

[[Category: Mus musculus]]

[[Category: Ghosh, G.]]

[[Category: Ghosh, G]]

[[Category: Huang, D B.]]

[[Category: Huang, D B]]

[[Category: Vu, D.]]

[[Category: Vu, D]]

[[Category: Activator]]

[[Category: Intertwined homodimer]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3juz|  PDB=3juz  |  SCENE=  }}
+==Crystal structure of a mutant of RelB dimerization domain(M5)==
-===Crystal structure of a mutant of RelB dimerization domain(M5)===
+<StructureSection load='3juz' size='340' side='right' caption='[[3juz]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zk9|1zk9]], [[3jtc|3jtc]], [[3jv0|3jv0]], [[3jv4|3jv4]], [[3jv5|3jv5]], [[3jv6|3jv6]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RelB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [http://www.ebi.ac.uk/pdbsum/3juz PDBsum]</span></td></tr>
-[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA].
+</table>
+__TOC__
-==Reference==
+</StructureSection>
-<references group="xtra"/><references/>
 [[Category: Mus musculus]]
-[[Category: Ghosh, G.]]
+[[Category: Ghosh, G]]
-[[Category: Huang, D B.]]
+[[Category: Huang, D B]]
-[[Category: Vu, D.]]
+[[Category: Vu, D]]
 [[Category: Activator]]
 [[Category: Intertwined homodimer]]