3p77: Difference between revisions

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{{STRUCTURE_3p77|  PDB=3p77  |  SCENE=  }}
==Crystal Structures of the Chicken YF1*7.1 molecule==
===Crystal Structures of the Chicken YF1*7.1 molecule===
<StructureSection load='3p77' size='340' side='right' caption='[[3p77]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
{{ABSTRACT_PUBMED_21151886}}
== Structural highlights ==
<table><tr><td colspan='2'>[[3p77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P77 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bev|3bev]], [[3bew|3bew]], [[3p73|3p73]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YFV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p77 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p77 RCSB], [http://www.ebi.ac.uk/pdbsum/3p77 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Chicken YF1 genes share a close sequence relationship with classical MHC class I loci but map outside of the core MHC region. To obtain insights into their function, we determined the structure of the YF1*7.1/beta(2)-microgloblin complex by X-ray crystallography at 1.3 A resolution. It exhibits the architecture typical of classical MHC class I molecules but possesses a hydrophobic binding groove that contains a non-peptidic ligand. This finding prompted us to reconstitute YF1*7.1 also with various self-lipids. Seven additional YF1*7.1 structures were solved, but only polyethyleneglycol molecules could be modeled into the electron density within the binding groove. However, an assessment of YF1*7.1 by native isoelectric focusing indicated that the molecules were also able to bind nonself-lipids. The ability of YF1*7.1 to interact with hydrophobic ligands is unprecedented among classical MHC class I proteins and might aid the chicken immune system to recognize a diverse ligand repertoire with a minimal number of MHC class I molecules.


==Function==
Structure of a classical MHC class I molecule that binds "non-classical" ligands.,Hee CS, Gao S, Loll B, Miller MM, Uchanska-Ziegler B, Daumke O, Ziegler A PLoS Biol. 2010 Dec 7;8(12):e1000557. PMID:21151886<ref>PMID:21151886</ref>
[[http://www.uniprot.org/uniprot/B2MG_CHICK B2MG_CHICK]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[3p77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P77 OCA].
</div>


==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Major histocompatibility complex|Major histocompatibility complex]]
*[[Major histocompatibility complex|Major histocompatibility complex]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021151886</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Daumke, O.]]
[[Category: Daumke, O]]
[[Category: Gao, S.]]
[[Category: Gao, S]]
[[Category: Hee, C S.]]
[[Category: Hee, C S]]
[[Category: Loll, B.]]
[[Category: Loll, B]]
[[Category: Miller, M M.]]
[[Category: Miller, M M]]
[[Category: Uchanska-Ziegler, B.]]
[[Category: Uchanska-Ziegler, B]]
[[Category: Ziegler, A.]]
[[Category: Ziegler, A]]
[[Category: Histocompatibility antigen]]
[[Category: Histocompatibility antigen]]
[[Category: Immune system]]
[[Category: Immune system]]
Retrieved from "https://proteopedia.org/3p77"