Sandbox Reserved 595: Difference between revisions
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=Function= | =Function= | ||
==Lipid Metabolism== | ==Lipid Metabolism== | ||
The protein, apolipoprotein E, has an important role in lipid metabolism; principally, it serves as a carrier protein. ApoE combines with lipids in the body to form lipoprotein particles (X,Z). These lipoprotein particles have hydrophobic lipids situated at the core and hydrophilic side chains made of amino acids (Z). Specifically, apoE is responsible for packaging cholesterol and other lipids and transporting them systemically (X,AA). | |||
==Immunological== | ==Immunological== | ||
ApoE can bind lipid antigens. Once binding occurs, apoE delivers the antigens, via receptor-mediated uptake, into endosomal compartments containing CD1 in antigen-processing cells. This protein can be secreted by antigen-presenting cells for the purpose of surveying the local environment and transfer microbial lipids from infected cells to bystander antigen-presenting cells. In one study, apoE mediated the presentation of serum-bovine lipid antigens. In this way, the immune system has co-opted a component of lipid metabolism in order to raise immunologic responses to lipid antigens (W). | ApoE can bind lipid antigens. Once binding occurs, apoE delivers the antigens, via receptor-mediated uptake, into endosomal compartments containing CD1 in antigen-processing cells. This protein can be secreted by antigen-presenting cells for the purpose of surveying the local environment and transfer microbial lipids from infected cells to bystander antigen-presenting cells. In one study, apoE mediated the presentation of serum-bovine lipid antigens. In this way, the immune system has co-opted a component of lipid metabolism in order to raise immunologic responses to lipid antigens (W). | ||
