3w8j: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3w8j| PDB=3w8j | SCENE= }} | |||
===Crystal structure of P5 a0 in a complex with Prx4 c-term=== | |||
{{ABSTRACT_PUBMED_23949117}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDIA6_HUMAN PDIA6_HUMAN]] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.<ref>PMID:15466936</ref> <ref>PMID:12204115</ref> [[http://www.uniprot.org/uniprot/PRDX4_MOUSE PRDX4_MOUSE]] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. | |||
==About this Structure== | |||
[[3w8j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W8J OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023949117</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Protein disulfide-isomerase]] | |||
[[Category: Inaba, K.]] | |||
[[Category: Kojima, R.]] | |||
[[Category: Suzuki, M.]] | |||
[[Category: Oxidoreductase-isomerase complex]] | |||
[[Category: Pdi family member]] | |||
[[Category: Protein disulfide isomerase]] | |||
[[Category: Thioredoxin fold]] | |||
Revision as of 10:45, 4 September 2013
Crystal structure of P5 a0 in a complex with Prx4 c-term
Template:ABSTRACT PUBMED 23949117
Function
[PDIA6_HUMAN] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.[1] [2] [PRDX4_MOUSE] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
About this Structure
3w8j is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Sato Y, Kojima R, Okumura M, Hagiwara M, Masui S, Maegawa K, Saiki M, Horibe T, Suzuki M, Inaba K. Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding. Sci Rep. 2013 Aug 16;3:2456. doi: 10.1038/srep02456. PMID:23949117 doi:10.1038/srep02456
- ↑ Jordan PA, Stevens JM, Hubbard GP, Barrett NE, Sage T, Authi KS, Gibbins JM. A role for the thiol isomerase protein ERP5 in platelet function. Blood. 2005 Feb 15;105(4):1500-7. Epub 2004 Oct 5. PMID:15466936 doi:10.1182/blood-2004-02-0608
- ↑ Kikuchi M, Doi E, Tsujimoto I, Horibe T, Tsujimoto Y. Functional analysis of human P5, a protein disulfide isomerase homologue. J Biochem. 2002 Sep;132(3):451-5. PMID:12204115
