4jm0: Difference between revisions
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{{STRUCTURE_4jm0| PDB=4jm0 | SCENE= }} | |||
===Structure of Human Cytomegalovirus Immune Modulator UL141=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/UL141_HCMVM UL141_HCMVM]] Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand PVRL2/Nectin-2 for proteasome-mediated degradation.<ref>PMID:20410314</ref> | |||
==About this Structure== | |||
[[4jm0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Nemcovicova, I.]] | |||
[[Category: Zajonc, D M.]] | |||
[[Category: Cd155]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Glycosylation]] | |||
[[Category: Host-virus interaction]] | |||
[[Category: Ig-like beta sandwich domain]] | |||
[[Category: Immunoglobulin-like v-set folg of n-terminal domain]] | |||
[[Category: Membrane]] | |||
[[Category: Trail-r2]] | |||
[[Category: Viral immunomodulator]] | |||
[[Category: Viral protein in complex with human receptor]] | |||