4f45: Difference between revisions

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~~{{STRUCTURE_4f45| PDB=4f45 | SCENE= }}~~

==Crystal structure of human CD38 E226Q mutant in complex with NAADP==

===Crystal structure of human CD38 E226Q mutant in complex with NAADP===

== Structural highlights ==

<table><tr><td colspan='2'>[[4f45]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F45 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F45 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DN4:[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>DN4</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4f46|4f46]]</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f45 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f45 RCSB], [http://www.ebi.ac.uk/pdbsum/4f45 PDBsum]</td></tr>

</table>

==~~Function~~==

==See Also==

[[~~http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN~~]] ~~Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.~~

*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]

__TOC__

~~==About this Structure==~~

</StructureSection>

~~[[4f45]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki~~/~~Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F45 OCA].~~

[[Category: Homo sapiens]]

[[Category: Hao, Q.]]

[[Category: Hao, Q]]

[[Category: Lee, H C.]]

[[Category: Lee, H C]]

[[Category: Zhang, H.]]

[[Category: Zhang, H]]

[[Category: Adp-ribosyl cyclase]]

[[Category: Calcium signaling]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4f45|  PDB=4f45  |  SCENE=  }}
+==Crystal structure of human CD38 E226Q mutant in complex with NAADP==
-===Crystal structure of human CD38 E226Q mutant in complex with NAADP===
+<StructureSection load='4f45' size='340' side='right' caption='[[4f45]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4f45]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F45 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DN4:[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>DN4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f46|4f46]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f45 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f45 RCSB], [http://www.ebi.ac.uk/pdbsum/4f45 PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
+*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4f45]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F45 OCA].
 [[Category: Homo sapiens]]
-[[Category: Hao, Q.]]
+[[Category: Hao, Q]]
-[[Category: Lee, H C.]]
+[[Category: Lee, H C]]
-[[Category: Zhang, H.]]
+[[Category: Zhang, H]]
 [[Category: Adp-ribosyl cyclase]]
 [[Category: Calcium signaling]]