2e25: Difference between revisions

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[[Image:2e25.jpg|left|200px]]<br /><applet load="2e25" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2e25.jpg|left|200px]]
caption="2e25, resolution 2.70&Aring;" />
 
'''The Crystal Structure of the T109S mutant of E. coli Dihydroorotase complexed with an inhibitor 5-fluoroorotate'''<br />
{{Structure
|PDB= 2e25 |SIZE=350|CAPTION= <scene name='initialview01'>2e25</scene>, resolution 2.70&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=FOT:5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID'>FOT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3]
|GENE= PYRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''The Crystal Structure of the T109S mutant of E. coli Dihydroorotase complexed with an inhibitor 5-fluoroorotate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2E25 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=FOT:'>FOT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E25 OCA].  
2E25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E25 OCA].  


==Reference==
==Reference==
Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form., Lee M, Maher MJ, Guss JM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt, 3):154-61. Epub 2007 Feb 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17329804 17329804]
Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form., Lee M, Maher MJ, Guss JM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt, 3):154-61. Epub 2007 Feb 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17329804 17329804]
[[Category: Dihydroorotase]]
[[Category: Dihydroorotase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: tim barrel]]
[[Category: tim barrel]]


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