3ksl: Difference between revisions
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Revision as of 20:11, 4 April 2013
Structure of FPT bound to DATFP-DH-GPP
Template:ABSTRACT PUBMED 19954434
Function
[FNTB_RAT] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
About this Structure
3ksl is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Hovlid ML, Edelstein RL, Henry O, Ochocki J, DeGraw A, Lenevich S, Talbot T, Young VG, Hruza AW, Lopez-Gallego F, Labello NP, Strickland CL, Schmidt-Dannert C, Distefano MD. Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. Chem Biol Drug Des. 2010 Jan;75(1):51-67. PMID:19954434 doi:10.1111/j.1747-0285.2009.00914.x
